Study suggests aerobic exercise lowers risk of metastatic cancer | News

Nov 20, 2022, 11:38PM ISTSource: ANI

According to a new study, aerobic exercise can reduce the likelihood of cancer metastatic spread by 72 percent. According to the researchers, during vigorous aerobic exercise, the amount of glucose (sugar) absorbed by internal organs increases, which reduces the amount of energy cancer has access to. Professor Carmit Levy from the Department of Human Genetics and Biochemistry and Dr Yftach Gepner from the School of Public Health and the Sylvan Adams Sports Institute at TAU’s Sackler Faculty of Medicine led the study. Prof. Levy notes that the new study has produced a significant discovery that could aid in the prevention of metastatic cancer, the main cause of mortality in Israel, by merging scientific expertise from many schools at TAU. The article was accepted for publication in the esteemed journal Cancer Research, and its cover was picked for the November 2022 issue. The study combined an animal model in which mice were trained under a strict exercise regimen, with data from healthy human volunteers examined before and after running. The human data, obtained from an epidemiological study that monitored 3,000 individuals for about 20 years, indicated 72 percent less metastatic cancer in participants who reported regular aerobic activity at high intensity, compared to those who did not engage in physical exercise. The animal model exhibited a similar outcome, also enabling the researchers to identify its underlying mechanism. Sampling the internal organs of the physically fit animals, before and after physical exercise, and also following the injection of cancer, they found that aerobic activity significantly reduced the development of metastatic tumours in the lymph nodes, lungs, and liver. The researchers hypothesized that in both humans and model animals, this favourable outcome is related to the enhanced rate of glucose consumption induced by exercise.

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