Pharmaceuticals

Eli Lilly (LLY): Right Industry, Wrong Price (NYSE:LLY)

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Introduction

I give Eli Lilly (NYSE:LLY) a sell rating. While I am bullish on the pharmaceutical space due to the rocky times in the future, I cannot be bullish on Eli Lilly due to its valuation.

Eli Lilly five-year stock

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Name Symbol % Assets
Axsome Therapeutics, Inc. (AXSM) 8.56%
Cassava Sciences, Inc. (SAVA) 5.11%
Elanco Animal Health Inc. (ELAN) 4.74%
Johnson & Johnson (JNJ) 4.60%
Catalent, Inc. (CTLT) 4.57%
Bristol-Myers Squibb Company (BMY) 4.57%
Pfizer Inc. (PFE) 4.49%
Perrigo Company PLC (PRGO) 4.23%
Corcept Therapeutics Inc. (CORT) 3.94%
Nektar Therapeutics (NKTR) 3.88%

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valuations of LLY

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These hopes have largely been fueled by LLY’s robust product pipeline. The company intends to launch five new medicines by the end of 2023. Of the five candidates, two have strong sales potential and have caught the attention of investors. These are Mounjaro (tirzepatide), which has been promoted as a weight loss treatment, and donanemab, for early Alzheimer’s disease…

Another factor that investors could have priced in is the fact that LLY is highly committed to R&D, which is what drives value creation in healthcare. 25 cents of every dollar in sales is funneled to R&D while 2 in every 10 of its workers work in R&D, according to data on its website. The earnings potential that comes with this level of investment in R&D is high…

Finally, another possible reason why investors are looking past LLY’s high valuation is the signals the management is sending out about potential future cash generation. The company has been growing its dividend consistently since 2014, with the latest payout growth being 15%.

Aduhelm had such a controversial approval and was later not covered by Medicare because of a set of issues that appears to be shared across Amyloid theory drugs. Amyloid therapies are known to cause “amyloid-related imaging abnormalities (ARIA), referring to swelling/edema (ARIA-E) or bleeding/hemorrhage (ARIA-H) in the brain.”

Moreover, these drugs appear to have a limited patient population for which they are genuinely effective. APOE4 is considered the most decisive risk factor for AD, 25% of people carry one gene, and 2% have two genes. This gene causes an increased build-up of amyloid, which is likely why this subpopulation sees the best results; however, they also experience the most substantial side effects from this drug class, such as the ARIA mentioned above.

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